Synthesis and Biological evaluation of pyrrolo[2, 3-d]pyrimidine derivatives as antibacterial and antiviral

A new class of pyrrolo[2,3-d] pyrimidine derivatives has been designed and synthesized, then examined and evaluated for their antiviral and antibacterial activity. New prophylactic therapeutic tools are needed for the treatment of highly pathogenic avian influenza (HPAI) H5N1 and highly virulent Newcastle disease virus (NDV). 3a, 3b, 3g, 3h have shown to posses highly potent against highly pathogenic avian influenza (HPAI) H5N1 virus and 1a, 2a are shown highly potent against highly virulent Newcastle disease virus (NDV),and the compounds 1a-c , 2a, 2b, 3a, 3g, 3h are shown highly potent against enterobacteriases [Escherichia coli and Salmonella typhimurium] strains. This study is the first record in Egypt and may be in the world concerning the activity of these new class of pyrrolo[2,3d]pyrimidine derivatives against (HPAI) H5N1 and NDV.